By Stephen P. H. Alexander, David A. Kendall (auth.), Dave Kendall, Stephen Alexander (eds.)
The endocannabinoid signalling method is among the key modulators of crucial fearful functionality. This quantity presents well timed and in-depth assurance of the jobs of the endocannabinoid signalling method within the neurobiology of habit. it's crucial interpreting for any researcher with a history in neuroscience eager to recognize extra concerning the endocannabinoids. the 1st part offers a accomplished account of the part components of the procedure (the signalling molecules, artificial and degradative enzymes and receptors), their position in the important anxious method and the endocannabinoids’ roles in neural plasticity. This part additionally describes the toolboxes (genetic and pharmacological) used to review the method. the second one part concentrates on endocannabinoid functionality within the regulate of ordinary physiological behaviors together with a connection with the evolution of the procedure in accordance with its operation in non-mammalian vertebrates. the amount concludes via addressing the significance of the endocannabinoids in pathological behaviors together with affective and cognitive problems, neurodegenerative stipulations, feeding and drug abuse.
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Extra info for Behavioral Neurobiology of the Endocannabinoid System
Sample text
46 Structural Characteristics of the CB1 Receptor . . . . . . . . . . . . . . . . . . . . . . 46 Structural Characteristics of the CB2 Receptor . . . . . . . . . . . . . . . . . . . . . . 48 CB1 and CB2 Receptor Localization. . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Cellular Signaling of CB1 and CB2 Receptors. . . . .
57 12 Conclusions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 Abstract This chapter will review the basic pharmacology of endocannabinoid receptors. As the best-described cannabinoid receptors are G-protein-coupled receptors (GPCRs), those will be the focus of this chapter.
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