By Doris Teichler Zallen, D. A. Christie, E. M. Tansey (Editors)

The Wellcome belief Centre for the historical past of medication at UCL produces a variety of courses, together with the Wellcome Witnesses to 20th Century medication sequence. those volumes are edited transcripts of Witness Seminars at which major figures in twentieth-century medication talk about discoveries and occasions in contemporary clinical heritage. Twenty-two released volumes can be found from December 2004. For extra info see: www.ucl.ac.uk/histmed/witnesses.html The prevention of rhesus sickness of the baby stands as a gorgeous scientific good fortune tale. This disorder hundreds of thousands of newborns every year, inflicting critical illnesses, even loss of life. but from the early Forties to the Seventies British and American researchers exposed the root of the illness and built the clinical intervention which could hinder its prevalence. the various key steps resulting in this notable fulfillment came about on the college of Liverpool institution of medication. Chaired by way of Professor Sir David Weatherall this Witness Seminar, 'The Rhesus issue and disorder prevention' (volume 22), examines the criteria that brought on those reviews and the demanding situations confronting scientists and clinicians; the highbrow, institutional, and social components that guided the paintings; the the most important insights; and the vistas that the prevention of Rh ailment has opened in fetal drugs. individuals contain Professor Robin Coombs, the past due Professor Ronald Finn, Dr Nevin Hughes-Jones, Professor Patrick Mollison, Dr Archie Norman, Dr Derrick Tovey, Professor Charles Whitfield, Professor John Woodrow and Professor Doris Zallen.

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The Rhesus Factor and Disease Prevention design and statistics. Finally, last but by no means least, the charismatic leader of our team, Sir Cyril Clarke, who had the uncanny knack of making things happen. No matter what Wiener had said, or did not say, Cyril Clarke would have gone in this direction, I have no doubt. If Cyril Clarke had not suggested that we work on ABO incompatibility as a protective mechanism, the whole thing would never have happened. His remarkable journey from butterflies to rhesus certainly deserves a place in medical history.

Finn: Yes. It was about 1956 or 1957, and I started in 1958, so we were very, very fortunate. As you were saying before, whatever the theory says, you have got to have the right technology, and it came along for us just at the right time. 80 Kleihauer et al. (1957); Zipursky et al. (1959); Zipursky and Israels (1967). Professor Ronald Finn enclosed an illustration of fetal cells erythrocytes in the maternal circulation in a letter to Dr Daphne Christie, 25 November 2003. This will be deposited with the records of this Witness Seminar in Archives and Manuscripts, Wellcome Library, London.

39 Lathe et al. (1958): 87–124, 125–44. The Rhesus Factor and Disease Prevention addition, exchange transfusion had become accepted. At that time I did most of the exchanges at Queen Charlotte’s Hospital, London, and, I must say, an exchange transfusion even then was a matter of some anxiety. 40 To get a rather firm plastic catheter into the umbilical vein of a small, perhaps anaemic and rather ill, baby was not always easy, and the estimations of the amount of blood you gave them also needed care.

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