By Donard Dwyer
At present, few medications can be found for the powerful remedy of neurodegenerative ailments and neurodevelopmental problems. fresh advances in neuroscience examine supply wish that destiny ideas for treating those mind issues will contain neurogenesis and neuroenhancement as healing endpoints. This quantity reports state of the art findings regarding the pharmacological facets of neurogenesis and neuroprotection. A extensive diversity of themes are coated from easy lab bench examine to drug discovery efforts and critical medical concerns. This selection of studies is an ideal method to develop into conversant in those fascinating new fields within the house of a unmarried quantity. Chapters are written with a normal viewers in brain, yet with sufficient high-level dialogue to entice experts and specialists in addition. The authors have performed a very good activity of difficult present paradigms and pushing the bounds of exploration based on the pioneering spirit that gave upward thrust to those rising parts of study. therefore, it will be an fundamental source for a few years to return. * presents cutting-edge experiences spanning major rising fields* Discusses destiny instructions and questions for destiny experiences* contains informative illustrations*
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Additional info for The Pharmacology of Neurogenesis and Neuroenhancement
Example text
FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice. J. Clin. Invest. 112, 1202–1210. , Ho, K. , and Chopp, M. (2004a). Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats. J. Cereb. Blood Flow Metab. 24, 441–448. , and Chopp, M. (2004b). Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal diVerentiation in the adult rat.
F. (1993). Cloning and growth of multipotential neural precursors: Requirements for proliferation and diVerentiation. Neuron 10, 255–265. Kim, J. , Auerbach, J. , Rodriguez-Gomez, J. , Lee, S. , and McKay, R. (2002). Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson’s disease. Nature 418, 50–56. , and Goldman, S. A. (1995). Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone. Proc. Natl.
And Greenberg, D. A. (2002c). Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc. Natl. Acad. Sci. USA 99, 11946–11950. , Mao, X. , and Greenberg, D. A. (2003). Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol. Cell Neurosci. 24, 171–189. , Mao, X. , Gorostiza, O. , Bredesen, D. , and Greenberg, D. A. (2004a). Enhanced neurogenesis in Alzheimer’s disease transgenic (PDGF-APPSw,Ind) mice. Proc. Natl. Acad. Sci.