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18). B. Effect on cigarette smoke-induced lung damage in mice Mice were smoked by ten or twenty ignited cigarettes for 45 min twice a day (in the morning and afternoon,) for ten consecutive days. Lung tissue of the cigarette smoke-intoxicated mice were taken for tissue sectioning and microscopic examination. Results from microscopic examination indicated that the adhesive membrane in pulmonary bronchioles of control mice were intact, without any upper epithelial proliferation. In addition, no inflammatory cell infiltration was found in the inner and outer wall of bronchioles, and the size of alveolar sac was normal.

1990). B. Effect on MMC-induced morphological and functional changes in cultured rat cardiomyocytes MMC did not produce any immediate effect on the beating performance of cardiomyocytes, however, the degree of influence was increased with time. Six hours after the addition of MMC at a final concentration of 1 mg/ml, the beating performance of cardiomyocytes was attenuated, with the reduced amplitude of contraction being associated with a lowered frequency, but normal rhythm of beating. Twenty-four hours after the administration of MMC, the beating performance was further attenuated, with a further decrease in beating frequency associated with abnormal rhythm.

E. 13) (Liu et al. 1990). C. Noradrenergic system One hour after the oral treatment with SMS at a dose of 11 g/kg, the noradrenaline (NA) level was significantly elevated in the rat heart, but the effect only lasted for 2 hr, with the NA level being returned to normal. 14) (Liu et al. 1990). In summary, oral treatment of rats with SMS (11 g/kg) could significantly decrease the level of DA in the peripheral zone of proencephalon, while the levels of DOPAC and HVA (DA metabolites) as well as 5-HIAA (serotonin metabolite) were significantly elevated.