By Vera Regitz-Zagrosek
This is the first actual e-book to accommodate intercourse and gender modifications in drug remedy - an more and more famous clinical desire. It starts off with an summary on S/G in medical syndromes and a documentation of the scientific and socioeconomic harm as a result of gender particular opposed drug results. half I covers S/G adjustments in pharmacokinetics. Researchers may be happy through the distinct dialogue of the mechanisms of S/G transformations in drug results that represents innovative technology and contains interplay of substances with intercourse hormones, genomic and epigenetic mechanisms. It additionally covers S/G in drug improvement, in animal types and medical improvement and S/G in drug prescriptions. half II pursuits S/G modifications in drug results in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic illnesses, in melanoma, irritation, and rheumatic illnesses, in bacterial and retroviral infections, thrombosis, embolism. New medications may be discussed.
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Additional resources for Sex and Gender Differences in Pharmacology
Sample text
3 Sex Differences in Models of Pathological Myocardial Hypertrophy: Volume Overload and Mineralcorticoide Excess . . . . . . . . . . . . . . . . . . . . . . . 4 Sex Differences in Models of Myocardial Injury . . . . . . . . . . . . . . . . . . . 3 Sex Differences in Transgenic Mouse Models of Heart Disease . . . . . . . . . . . . . 4 Potential Molecular Mechanisms Involved in the Sex-Based Differences in the Physiology and Pathophysiology of Myocardium: The Role of E2/ER .
4 Potential Molecular Mechanisms Involved in the Sex-Based Differences in the Physiology and Pathophysiology of Myocardium: The Role of E2/ER . . . . . . . . . . 1 Molecular Mechanisms Involved in Physiological Hypertrophy . . . . . . . . . . 2 Molecular Mechanisms Involved in Pathophysiology of MH and HF . . . . . . . . 5 Conclusions and Clinical Implications . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . .
2006) Reference(s) Schaible and Scheuer (1979) and Schaible and Scheuer (1981) Schaible and Scheuer (1981) Konhilas et al. (2004) 28 S. Mahmoodzadeh et al. d. not determined I/R Pathological Mouse Mouse Rat Rat Rat Rat Rat Mouse Mouse Mouse Rat, dog Significantly smaller infarct size, increased activation of sarcKATP- and mitoKATPchannels in female hearts Less LVH in females Gene cluster response-sex-specific manner to PO LVH greater in WT males, BERKO mice no SD in LVH, BERKO females highest levels of fibrosis, sex- and genotype-specific gene expression Early transition to HF with cavity dilatation, loss of concentric remodeling elevated wall, and diastolic dysfunction in males Males develop diastolic dysfunction, elevated wall stress, and depressed contractile reserve.