By Marcelo E. Tolmasky, Juan Carlos Alonso

An very good textbook for upper-level undergraduate and graduate classes within the biosciences that includes a sequence of expertly written chapters describing the most recent advances within the simple wisdom of plasmid biology, the really expert capabilities plasmids confer to the host cellphone, and the sensible usage of plasmids for discovery, drugs, and agriculture.

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Extra info for Plasmids : biology and impact in biotechnology and discovery

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11. Lederberg J. 1998. Plasmid (1952–1997). Plasmid 39: 1–9. 12. Bukhari AI, Shapiro JA, Adhya SL (ed). 1977. DNA Insertion Elements, Plasmids, and Episomes. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 13. Zhou Y, Call DR, Broschat SL. 2012. Genetic relationships among 527 Gram-negative bacterial plasmids. Plasmid 68:133–141. 14. Novick RP. 1987. Plasmid incompatibility. Microbiol Rev 51:381–395. 15. Kado CI, Helinski DR. 2007. Proceedings of the international symposium on plasmid biology.

1. HISTORICAL EVENTS THAT SPAWNED THE FIELD FUNCTIONAL ATTRIBUTES REQUIRED FOR PLASMID PERSISTENCE AND SURVIVAL Conjugative transfer of plasmids reflects an indispensable trait required for their ensured survival as selfish DNA molecules (56, 59). Traits such as conferring antibiotic resistance were first recognized as being plasmidborne in Shigella and Salmonella spp. as described in the introduction above. Antibiotic resistance conferred by plasmid genes provided survival value to pathogens that would otherwise be killed by the antibiotic(s).

Proc Natl Acad Sci USA 63:1164–1168. Bramhill D, Kornberg A. 1988. Duplex opening by dnaA protein at novel sequences in initiation of replication at the origin of the E. coli chromosome. Cell 52: 743–755. Gerdes K, Møller-Jensen J, Bugge Jensen R. 2000. Plasmid and chromosome partitioning: surprises from phylogeny. Mol Microbiol 37:455–466. Nordstro¨m K, Austin SJ. 1989. Mechanisms that contribute to the stable segregation of plasmids. Annu Rev Genet 23:37–69. Meacock PA, Cohen SN. 1980. Partitioning of bacterial plasmids during cell division: a cis-acting locus that accomplishes stable plasmid inheritance.

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