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In the preceding paragraphs we discussed the noise part of SNR, which depends mainly on slice thickness and x-ray power and exposure time, as expressed by milliampere-seconds (mAs). But equally important is the determination of the signal. In CT the signal is represented as the contrast between adjacent tissues or structures to be imaged. CT tissue contrast varies from approximately 1000 Hounsfield units (HU) to less than 10 HU, a range of 100:1. 1. Thus, bone and lung imaging involve a high signal, so a good SNR can be obtained with lower radiation exposure or thinner slices.
Both modalities have their strengths; CT scanners image anatomy with high spatial resolution, while PET can identify a functional abnormality in, for example, myocardial perfusion and metabolism. To initiate the evolution in imaging technology that was required to physically integrate CT and PET1 in a single device, the design and development of a research prototype PET/CT scanner was undertaken with NIH support. The fi rst combined PET/CT prototype scanner was completed in 1998, 2 and clinical evaluation began in June of that year; initial studies with the prototype focused primarily on cancer.
Oldendorf WH. Isolated flying spot detection of radiodensity discontinuities—displaying the internal structural pattern of a complex object. Ire Trans Biomed Electron. 1961;8: 68–72. 5. Kuhl DE, Edwards RQ. Image separation isotope scanning. Radiology 1963;80:653. 6. Hounsfield GN. Computerized transverse axial scanning (tomography). 1. Description of system. Br J Radiol. 1973;46:1016–1022. 7. Ambrose J. Computerized transverse axial scanning (tomography). 2. Clinical application. Br J Radiol. 1973;46:1023–1047.