By Andreas Offenhäusser, Ross Rinaldi
The varied points of bioelectronics reviewed during this booklet emphasize the colossal advancements within the box of bioelectronics and nano-bioelectronics. the diversity of issues addressed emphasize key features and the longer term views of nano-bioelectronics. The e-book discusses the digital coupling of DNA and proteins with digital units to construct new info structures and to use the platforms as biosensors. The exploitation of networks of neurons attached with digital units in destiny info processing platforms and using nano-objects to evaluate mobile functionality is usually mentioned intimately. a few of the subject matters addressed during this booklet may be of curiosity to physicists, chemists, biologists, fabric scientists and engineers, in addition to allure younger researchers and introduce them to the sector with a tremendous selection of literature references.
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Example text
2006). Their method bases on the concept of forming DNA tile structures via the self-assembly of a set of single-stranded DNA. Thereby, the DNA tiles carry “sticky ends” that allow recognizing the complementary sticky ends of other DNA tiles, whereby the second involved DNA tile is bound to a gold nanoparticle. Thus, they prepared relatively rigid cross structures composed of four four-arm DNA branch junctions (Fig. 11). The formed lattice structures were proven by AFM studies. DNA-MEDIATED ASSEMBLY OF METAL NANOPARTICLES 25 FIG.
Right: Height profile of the surface (Reproduced from Koplin et al. ). FIG. 8. Admittance spectra (plot of Y’ vs. υ) of gold nanoparticle monolayers, immobilized on silicon substrates via specific DNAhybridization for temperatures in between 75 and 300 K. The arrow indicates increasing temperature) (Reproduced from Koplin et al. ). 24 DNA-BASED NANOBIOELECTRONICS Another approach to obtain ordered two-dimensional networks with defined particle spacings utilizes oligofunctional gold nanoparticles containing different DNA sequences (Fig.
Most recently, Huang and co-workers reported the assembly of gold nanoparticles and further development to metallic wires by electroless plating using M13 phage, a filamentous virus, as template, which had been genetically engineered (Huang et al. 2005). Koyfman and co-workers showed the assembly of cationic gold nanoparticles by a ladder of RNA-building blocks, so-called tectosquares (Koyfman et al. 2005). FIG. 17. TEM images showing the process of the nanogap formation. A. Biotin DNA template after incubation with DMAP stabilized nanoparticles.