By Andrew J. Pollard, Martin C.J. Maiden
Andrew Pollard and Martin Maiden have assembled a magnificent number of the most recent molecular and mobile concepts for the advance, assessment, and implementation of vaccines for use in contrast dreaded illness. The contributors-leading scientists, clinicians, and public well-being physicians-describe intimately the numerous techniques to vaccine layout, in addition to the overview of immune reaction to vaccine applicants and novel vaccine formulations. well timed and complete, Meningococcal Vaccines: tools and Protocols offers the scientist, public wellbeing and fitness medical professional, epidemiologist, medical microbiologist, and clinician with the basic instruments to put naked the secrets and techniques of the meningococcus, and to strengthen, assessment, and enforce winning new meningococcal vaccines.
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Extra resources for Meningococcal Vaccines: Methods and Protocols (Methods in Molecular Medicine)
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9, 190–196. 18 Feavers 60. , Takala, A. , and Kayhty, H. (1993) Haemophilus influenzae type b polysaccharide-protein conjugate vaccines in children. Curr. Opin. Pediatr. 5, 55–59. 61. Moxon, E. , Heath, P. , Azzopardi, H. , Slack, M. , and Ramsay, M. E. (1999) 4th European conference on vaccinology: societal value of vaccination. The impact of Hib conjugate vaccines in preventing invasive H. influenzae diseases in the UK. Vaccine 17, S11–S13. 62. Goldblatt, D. (1998) Recent developments in bacterial conjugate vaccines.
The chapters in this book provide the tools for the further investigation of these fundamental issues relevant to a better understanding of meningococcal pathophysiology. A better understanding of these will allow more rational development of not only better therapeutic strategies but also better vaccine design. Antibodies to the non-B serogroup meningococci have been proven be critical for protection and polysaccharide vaccines are able to induce this in the short term. With protein-polysaccharide conjugate vaccines for serogroup C meningococci available, and others on the horizon, the potential to provide life-long protection is tantalizingly in our grasp.
For example, CD32 (FcaRIIa) polymorphisms are found more commonly in children with meningococcal disease (44) and a combination of FcaRIIa and FcaRIIIb polymorphisms are associated with an increased risk of meningococcal disease in individuals with a late complement component deficiency (45). 3. The Endothelium and the Inflammatory Response During growth in the blood, meningococci, in common with other Gramnegative bacteria, shed LPS-containing blebs of outer membrane. These blebs contain a full complement of meningococcal surface exposed structures and might act as a decoy for the host-immunologic defenses.