By Gareth Thomas
Medicinal Chemistry: An advent, moment version offers a accomplished, balanced creation to this evolving and multidisciplinary zone of study. development at the good fortune of the 1st variation, this version has been thoroughly revised and up to date to incorporate the most recent advancements within the field.
Written in an obtainable sort, Medicinal Chemistry: An creation, moment variation rigorously explains basic rules, assuming little within the manner of past wisdom. The booklet specializes in the chemical rules used for drug discovery and layout overlaying body structure and biology the place correct. It opens with a wide evaluate of the topic with next chapters interpreting themes in larger depth.
From the stories of the 1st Edition:
"It features a wealth of knowledge in a compact shape" ANGEWANDTE CHEMIE, overseas EDITION
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Extra resources for Medicinal Chemistry An Introduction
Sample text
For example, the development of penicillin by Florey and Chain was only possible because Alexander Fleming noted the inhibition of staphylococcus by Penicillium notatum. In spite of our increased knowledge base, it is still necessary to pick the correct starting point for an investigation if a successful outcome is to be achieved and luck still plays a part in selecting that point. This state of affairs will not change and undoubtedly luck will also lead to new discoveries in the future. However, modern techniques such as computerised molecular modelling (see Chapter 4) and combinatorial chemistry (see Chapter 5) introduced in the 1970s and 1990s, respectively, are likely to reduce the number of intuitive discoveries.
The degree of drug activity is directly related to the concentration of the drug in the aqueous medium in contact with the target molecule. 7 INTRODUCTION TO DRUG ACTION concentration in a biological system can be classified into the pharmacokinetic phase and the pharmacodynamic phase of drug action. The pharmacokinetic phase concerns the study of the parameters that control the journey of the drug from its point of administration to its point of action. The pharmacodynamic phase concerns the chemical nature of the relationship between the drug and its target, in other words, the effect of the drug on the body.
The first rational development of synthetic drugs was carried out by Paul Ehrlich and Sacachiro Hata who produced arsphenamine in 1910 by combining synthesis with reliable 4 CH1 AN INTRODUCTION TO DRUGS, THEIR ACTION AND DISCOVERY biological screening and evaluation procedures. Ehrlich, at the beginning of the nineteenth century, had recognised that both the beneficial and toxic properties of a drug were important to its evaluation. He realised that the more effective drugs showed a greater selectivity for the target microorganism than its host.