By Beverly McCabe-Sellers, Eric H. Frankel, Jonathan J. Wolfe
With contributions from the fields of pharmacy, dietetics, and drugs, guide of Food-Drug Interactions serves as an interdisciplinary advisor to the prevention and correction of damaging food-drug interactions. instead of easily checklist power food-drug interactions, this booklet presents causes and offers particular thoughts in accordance with the frequency and severity of reactions. each one bankruptcy brings jointly the original skills and information of practitioners in numerous disciplines who supply a transparent, thorough remedy of this significant topic.
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D. , Eds. , St. Louis, MO, updated quarterly. (This text is the touchstone for learning about drug–drug interactions. It details the mechanism of various drug interactions. F. , McGraw-Hill, New York, 1996. (This is the classic reference for pharmacology. , St. Louis, MO, updated quarterly. (Providing extensive information about drug–drug and drug–food interactions, this reference examines mechanisms, clinical significance, timing, and management of interactions. The information is quite clear and accessible.
2003 by CRC Press LLC Acidic degradation of acid-sensitive drugs is a primary concern when drugs and food are taken together. Classic examples of acid-sensitive drugs include aspirin and the various first-generation penicillins. If the residence time of these drugs in the stomach is increased by the presence of food, then the degradation of these drugs increases. As a result, the extent of drug absorption may be substantially reduced because the active degradation reduces the amount of drug available to be transported across the mucosa and distributed in the circulation.
Even food substances that are not absorbed, such as insoluble fiber, may be important to the digestive process of some nutrients. Drugs, on the other hand, almost always are degraded and made either useless or harmful if altered by the digestive process. Factors Affecting/Regulating Digestion Digestion of foods depends on the combination of macronutrients present and the digestive compounds released by the presence of specific macronutrients in the gut. Some nutrients are also influenced by the presence or absence of specific micronutrients.