By Peter Aspelin, Marie France Bellin, Jarl å. Jakobsen, Judith A. W. Webb (auth.), Henrik S. Thomsen MD, Judith A. W. Webb MD, FRCP, FRCR (eds.)
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Extra info for Contrast Media: Safety Issues and ESUR Guidelines
It is well known that reviewers with underlying ﬁnancial conﬂicts of interest are more likely to draw conclusions that favor an intervention, which beneﬁts the source of any ﬁnancial gain (Barnes and Bero 1998). Most studies performed on contrast agents are undertaken by investigators with either overt or probable conﬂicts of interest (Aspelin et al. 2003; Solomon et al. 2007). Whether these facts should just lead to more critical reading of their work or should stimulate a comprehensive reevaluation of their whole research project is best left to the reader’s discretion.
6 Conﬂicts of Interest and Funding Issues Another major threat to the validity of a systematic review, as to any other research project, depends on conﬂicts of interest and how studies are funded. It is well known that reviewers with underlying ﬁnancial conﬂicts of interest are more likely to draw conclusions that favor an intervention, which beneﬁts the source of any ﬁnancial gain (Barnes and Bero 1998). Most studies performed on contrast agents are undertaken by investigators with either overt or probable conﬂicts of interest (Aspelin et al.
This deﬁnition aims to distinguish them from chemotoxic reactions, which are dose-related and dependent on the physico-chemical properties of the contrast medium. However, in clinical practice, some reactions such as cardiovascular collapse may be difﬁcult to characterise deﬁnitely into one or the other group. Most of this chapter is concerned with acute idiosyncratic reactions to iodinated contrast media, particularly the factors predisposing to these reactions and the measures that may be taken to prevent them.