By Tanya Panchenko, Ben E. Black (auth.), Durdica Ugarkovic (eds.)
The centromere is a chromosomal locus that regulates the correct pairing and segregation of the chromosomes in the course of mobile department. regardless of their conserved, crucial functionality, centromeres are characterised by way of the swift evolution of either centromeric DNA and proteins.
This e-book provides present perspectives on centromere constitution and identification. It offers with the epigenetic proposal of centromere institution and upkeep in addition to with the function of DNA and centromeric transcripts in centromere formation and serve as. particular emphasis is put on centromere evolution: various evolutionary types are mentioned intimately and the most recent study at the evolution of recent centromeres and neocentromeres is presented.
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Additional info for Centromere: Structure and Evolution
More complex centromeres are found in fission yeast Schizosaccharomyces pombe (Clarke and Baum 1990; Wood et al. 2002). In contrast, centromeres in plants and animals are highly complex and consist of hundreds of kilobases of long arrays of satellite repeats (Copenhaver et al. 1999; Schueler et al. 2001). A further degree of complexity is evident in the centromeres of holokinetic organisms like Caenorhabditis elegans; centromeric determinants dispersed throughout the length of the chromosome that coalesce at metaphase, such that each centromere runs the entire length of the chromosome (Buchwitz et al.
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