By Tanya Panchenko, Ben E. Black (auth.), Durdica Ugarkovic (eds.)

The centromere is a chromosomal locus that regulates the correct pairing and segregation of the chromosomes in the course of mobile department. regardless of their conserved, crucial functionality, centromeres are characterised by way of the swift evolution of either centromeric DNA and proteins.

This e-book provides present perspectives on centromere constitution and identification. It offers with the epigenetic proposal of centromere institution and upkeep in addition to with the function of DNA and centromeric transcripts in centromere formation and serve as. particular emphasis is put on centromere evolution: various evolutionary types are mentioned intimately and the most recent study at the evolution of recent centromeres and neocentromeres is presented.

Show description

Read or Download Centromere: Structure and Evolution PDF

Similar biophysics books

Vice Presidents, 4th Edition (Political Biographies)

Political and historic, Vice Presidents collects the existence tales of each guy that has held this place of work. each one expertly written biography addresses the country of the rustic on the time those males have been in workplace and lines: An research of winning political stipulations The competition The relationships among the vice chairman and presidents The political machinations of those males, a few of whom won the last word prize, presidency an entire chronology of the political historical past of the USA from 1789 to 2000.

Metastasis of Breast Cancer (Cancer Metastasis - Biology and Treatment)

Metastasis (spread of melanoma within the physique) is the most reason for dying for sufferers with breast melanoma, the major lady tumour within the industrialised nations and constructing nations alike. The biology and remedy of breast melanoma metastasis continues to be an energetic sector of clinical and medical research.

Marijuana and Madness: Psychiatry and Neurobiology

This finished and up to date evaluation of the psychiatry and neuroscience of hashish sativa (marijuana) areas specific emphasis on psychotic problems. It outlines the newest study improving our wisdom of the human cannabinoid procedure, and hyperlinks it to medical and epidemiological proof concerning the effect of hashish on psychological wellbeing and fitness.

Biophysics and Structure to Counter Threats and Challenges

This ASI introduced jointly a various crew of specialists who span virology, biology, biophysics, chemistry, physics and engineering. favorite teachers representing international well known scientists from 9 (9) diverse international locations, and scholars from all over the world representing eighteen (18) nations, participated within the ASI equipped by means of Professors Joseph Puglisi (Stanford college, united states) and Alexander Arseniev (Moscow, RU).

Additional info for Centromere: Structure and Evolution

Sample text

More complex centromeres are found in fission yeast Schizosaccharomyces pombe (Clarke and Baum 1990; Wood et al. 2002). In contrast, centromeres in plants and animals are highly complex and consist of hundreds of kilobases of long arrays of satellite repeats (Copenhaver et al. 1999; Schueler et al. 2001). A further degree of complexity is evident in the centromeres of holokinetic organisms like Caenorhabditis elegans; centromeric determinants dispersed throughout the length of the chromosome that coalesce at metaphase, such that each centromere runs the entire length of the chromosome (Buchwitz et al.

PLoS Genet 3:1965–1974 Castillo AG, Mellone BG, Partridge JF, Richardson W, Hamilton GL, Allshire RC, Pidoux AL (2007) Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4. PLoS Genet 3:e121 Chen ES, Saitoh S, Yanagida M, Takahashi K (2003) A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast. Mol Cell 11:175–187 Chikashige Y, Kinoshita N, Nakaseko Y, Matsumoto T, Murakami S, Niwa O, Yanagida M (1989) Composite motifs and repeat symmetry in S.

Genome Res 14:1696–1703 Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, Moazed D (2004) RNAi-mediated targeting of heterochromatin by the RITS complex. Science 303:672–676 Volpe TA, Kidner C, Hall IM, Teng G, Grewal SI, Martienssen RA (2002) Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297:1833–1837 Voullaire LE, Slater HR, Petrovic V, Choo KH (1993) A functional marker centromere with no detectable alpha-satellite, satellite III, or CENP-B protein: activation of a latent centromere.

Download PDF sample

Rated 4.53 of 5 – based on 7 votes