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Rising treatments for BPD - akin to Inhaled Nitrous Oxide, diet A, Antioxidant ideas, and low-dose steroid treatment
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Additional resources for Bronchopulmonary Dysplasia, Volume 240 (Lung Biology in Health and Disease)
51. Weaver M, Yingling JM, Dunn NR, et al. Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. Development 1999; 126:4005–4015. 52. Hackett BP, Brody SL, Liang M, et al. Primary structure of hepatocyte nuclear factor/ forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium. Proc Natl Acad Sci U S A 1995; 92:4249–4253. 53. Brody SL, Yan XH, Wuerffel MK, et al. Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice.
EGF is also expressed in mature AEC and regulates type 2 cell proliferation through an autocrine mechanism both in culture and in vivo (144). However, respiratory epithelial cell overexpression of TGF-a under the control of the Sp-C promoter of transgenic mice induces postnatal lung fibrosis (145). Overexpression of TGF-a caused severe pulmonary vascular disease, which was mediated through EGFR signaling in distal epithelial cells. Reductions in VEGF may contribute to the pathogenesis of pulmonary vascular disease in TGF-a mice (146).
52. Hackett BP, Brody SL, Liang M, et al. Primary structure of hepatocyte nuclear factor/ forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium. Proc Natl Acad Sci U S A 1995; 92:4249–4253. 53. Brody SL, Yan XH, Wuerffel MK, et al. Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am J Respir Cell Mol Biol 2000; 23:45–51. 54.