By Rodney J. Y. Ho
Biotechnology and Biopharmaceuticals: remodeling Proteins and Genes into medicinal drugs defines biotechnology from the point of view of prescription drugs. the 1st part makes a speciality of the method of remodeling a biologic macromolecule right into a healing agent, whereas the second one part presents a quick evaluate of every classification of macromolecule with appreciate to physiological function and scientific software. extra element can be supplied within the moment part for every FDA licensed, recombinantly derived biopharmaceutical for every class of macromolecule. the ultimate part appears to be like to the long run and the hot advances that may improve our skill to boost new macromolecules into potent biopharmaceuticals. This final part discusses a variety of drug supply techniques whereas additionally describing gene and cellphone treatment suggestions.
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Extra resources for Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs
Recombinant cytokines, when injected into the bloodstream, may encounter various cytokine-binding proteins including soluble cytokine receptors and anti-cytokine antibodies. In either case, the binding protein may either prolong the cytokine circulation time by acting as a storage depot, or it may enhance the cytokine clearance . Growth hormone, for example, has at least two binding proteins in plasma ; this protein binding substantially reduces growth hormone elimination with a tenfold smaller clearance of total compared to free growth hormone, but also decreases its activity via reduction of receptor interactions.
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