By Rodney J. Y. Ho
Biotechnology and Biopharmaceuticals: remodeling Proteins and Genes into medicinal drugs defines biotechnology from the point of view of prescription drugs. the 1st part makes a speciality of the method of remodeling a biologic macromolecule right into a healing agent, whereas the second one part presents a quick evaluate of every classification of macromolecule with appreciate to physiological function and scientific software. extra element can be supplied within the moment part for every FDA licensed, recombinantly derived biopharmaceutical for every class of macromolecule. the ultimate part appears to be like to the long run and the hot advances that may improve our skill to boost new macromolecules into potent biopharmaceuticals. This final part discusses a variety of drug supply techniques whereas additionally describing gene and cellphone treatment suggestions.
Read Online or Download Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs PDF
Best pharmacy books
Free Energy Calculations in Rational Drug Design
Unfastened strength calculations symbolize the main exact computational process to be had for predicting enzyme inhibitor binding affinities. Advances in computing device strength within the Nineteen Nineties enabled the sensible program of those calculations in reason drug layout. This booklet represents the 1st complete overview of this becoming region of analysis and covers the fundamental idea underlying the tactic, a variety of state-of-the-art suggestions designed to enhance throughput and dozen examples in which unfastened power calculations have been used to layout and assessment power drug applicants.
The School of Pharmacy, University of London. Medicines, Science and Society, 1842–2012
The college of Pharmacy, collage of London: medications, technology and Society, 1842-2012 represents the wealthy historical past of the collage of London college of Pharmacy via a variety of colour pictures, vital advances within the pharmacy career, cultural milestones, biographies and extra. Written in an interesting and authoritative variety, this publication depicts the chronological historical past of the varsity from its institution in 1842 to the current day with a nod towards its aspirations for the longer term.
This quantity offers the reader with contemporary advances within the fields of molecular toxinology, the biotechnological purposes of venom pollution, and antivenom construction. The content material of the twenty chapters of Venom Genomics and Proteomics illustrates not just the large growth made because the implementation of omics applied sciences within the box of toxinology, yet one additionally realizes the line nonetheless forward to arrive a holistic view of venomous structures.
Pharmaceutical Process Scale-Up
Targeting clinical and useful elements of approach scale-up, this source information the idea and perform of shifting pharmaceutical strategies from laboratory scale to the pilot plant and construction scale. It covers parenteral and nonparenterel beverages and semi-solids, items derived from biotechnology, dry mixing and powder dealing with, granulation and drying, fluid mattress purposes, compaction and tableting, and movie coating and regulatory specifications for scale-up and postapproval adjustments.
Extra resources for Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs
Example text
Recombinant cytokines, when injected into the bloodstream, may encounter various cytokine-binding proteins including soluble cytokine receptors and anti-cytokine antibodies. In either case, the binding protein may either prolong the cytokine circulation time by acting as a storage depot, or it may enhance the cytokine clearance [62]. Growth hormone, for example, has at least two binding proteins in plasma [63]; this protein binding substantially reduces growth hormone elimination with a tenfold smaller clearance of total compared to free growth hormone, but also decreases its activity via reduction of receptor interactions.
32 : 259–267. M. Persky, G. Hochhaus, and B. Meibohm. 2004. Pharmacokinetic aspects of biotechnology products. J. Pharm. Sci. 93 : 2184–2204. Levy, G. 1994. Pharmacologic targetmediated drug disposition. Clin. Pharmacol. Ther. 56 : 248–252. , C. Berg, R. Nassr, and K. Pang. 2003. The further evolution of biotech. Nat. Rev. Drug Discov. 2 : 75–79. CDER/FDA. 2003. Exposure Response Relationships: Guidance for Industry. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Rockville.
Clin. Pharmacol. Ther. 56 : 248–252. , C. Berg, R. Nassr, and K. Pang. 2003. The further evolution of biotech. Nat. Rev. Drug Discov. 2 : 75–79. CDER/FDA. 2003. Exposure Response Relationships: Guidance for Industry. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Rockville. 6 Future 21 International Conference on Harmonization. 1994. ICH E4 – Dose-Response Information to Support Drug Registration. European Agency for the Evaluation of Medicinal Products, London.