By Martin Stefan, Mike Travis, Robin Murray
Written by means of a workforce of specialists operating on the leading edge of this box, An Atlas of Schizophrenia describes schizophrenia's profound results on notion, realizing, conversation, and social habit; its identifiable antecedents in early mind development and improvement; and its morphological information from structural mind imaging and autopsy experiences. It covers, with examples, the newest study advancements in neuropsychology, psychophysiology, and useful imaging in addition to in vivo receptor imaging and different advances in psychopharmacology which are laying off new gentle at the neurochemistry of schizophrenia.Diagrams, tables, and figures got via glossy imaging recommendations mixed with examples of work from the Bethlem Royal health facility files and Museum illustrate the human in addition to the medical and psychiatric points of the disease. those positive aspects offer you an entire photograph of schizophrenia, its analysis, and administration. With its mix of the most recent study and scientific information and cutting-edge mind imaging innovations, An Atlas of Schizophrenia presents a distinct visible presentation of the present realizing of the scientific positive aspects, etiology, pathophysiology, and cures on hand.
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Extra info for Atlas of Schizophrenia, Second Edition
Biol Psychiatry 1999; 46:56–72 CLASSIFICATION OF DOPAMINE RECEPTORS Dopamine D2 receptor family D1 receptor family D1 D5 Caudateputamen N. accumbens Olfactory tubercule Hippocampus Hypothalamus D2 D3 D4 Caudateputamen N. accumbens Olfactory tubercule Olfactory tubercule Hypothalamus N. 5 There are currently five types of dopamine receptor identified in the human nervous system, D1 to D5. D1 and D5 receptors are similar in that they both stimulate the formation of cAMP by activation of a stimulatory G-coupled protein.
7. 8. Van Horn JD, McManus IC. Ventricular enlargement in schizophrenia. A meta-analysis of studies of the ventricle : brain ration (VBR). Br J Psychiatry 1992;160:687–97 Suddath RL, Christison GW, Torrey EF, et al. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med 1990;322:789–34 Wright IC, Rabe-Hesketh S, Woodruff PW, et al. Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 2000;157:16–25 Akbarian S, Bunney WE, Jr, Potkin SG, et al.
21)16. Childhood ‘schizoid’ personality traits may reflect deficits in cognition and in social behavior that are part of the disease process itself. Abnormalities of social behavior, movement and posture have also been reported (for example, in studies based on old home movies of affected and unaffected siblings). The antecedents of schizophrenia may therefore become identifiable long before the clinical onset of the illness. 20 Wisconsin card sort test (WCST) in monozygotic twins discordant for schizophrenia.