By John M. Beale Jr. PhD, John Block
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Extra info for Wilson & Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry
Example text
Often an altered drug molecule known to combine with the receptor. is attached to a chrornatographic support phase. A solution containing the desired receptor is passed over this column. The receptor will combine with the ligand. It is common to add a chemically reactive grouping to the drug, resulting in the receptor and drug covalently binding with each other. The drug—receptor complex is washed from the column and then characterized further. A more recent technique uses recombinant l)NA. The gene for the receptor is located and cloned.
6; Eq. 5: Eq. 5 (stomach). 4 (plasma) (see examples 1,6, and 7 in Table 2-4). Of course, the effect of protein binding, discussed above, can greatly alter any prediction of biodistrihution based solely on STATISTICAL PREDICTION OF PHARMACOLOGICAL ACTIVITY Just as mathematical modeling is used to explain and model many chemical processes, it has been the goal of medicinal chemists to quantify the effect of a structural change on a defined pharmacological response. sted. This aspect of medicinal chemistry is coinmonly referred to as quantitative structure—activity relationships (QSAR).
Water solubility. electronic parameters, steric descriptors. and partition coefficients (Eq. 2-16). Today. the partition coefficient has beconte the single most important physical chemical tneasurernettt for QSAR studies. s + I,). so fliologienl Aelion tog BR = a(physicat chemical property) 17 c lFiq. 2-161 where BR = a defined pharmacological response usually expressed in miltimoles such as the mnhibbory constant K,. the cffecmive dose in St)'l of thc subjects the lethal dose in fit)% of the subjects (LD51).