By Davis, Andrew M.; Ward, Simon Edward
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For example, AstraZeneca has significantly reduced resource on neuroscience research and has moved to a virtual model where a small internal team collaborates with leading academic centres to share reward and risk. Pfizer has established Centres for Therapeutic Innovation in Boston, New York, San Diego and San Francisco to facilitate interactions with academic institutions, and has placed their own staff in collaborator laboratories. While these initiatives should provide early access to new biology, translation to successful drug discovery projects still has to be realised, and there will be the inevitable trade off between publications and IP.
Based on a dataset of B2000 oral drugs (data from reference 84 updated with drugs launched since 2011). 08:35:59. 1039/9781782621836-00001 Percentile Range Descriptor Mean Minimum Maximum Std. Dev. 1 Lipophilicity The terms lipophilicity and hydrophobicity are often used interchangeably, but IUPAC provides distinct definitions:3 Hydrophobicity is the association of non-polar groups or molecules in an aqueous environment, which arises from the tendency of water to exclude non-polar molecules. Lipophilicity represents the affinity of a molecule for a lipophilic environment.
GPCR and Kinase). 15 View Online 16 Chapter 1 08:35:59. 7 Effect of the Individual Chemist and the Organisation Drug discovery is a highly creative activity that has generated an armoury of 42000 medicines with a massive positive overall effect on human health. There is no prescribed way to invent a drug—the selection of a chemical starting point and the path taken to optimise it are prone to the intuitive, but also subjective, mind-set of the chemists and other scientists involved.