By V Alagarsamy
Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its area. specific normally to B. Pharm. scholars, this booklet can also be priceless for M. Pharm. in addition to M. Sc. natural chemistry and pharmaceutical chemistry scholars. It goals at casting off the inadequacies in instructing and studying of medicinal chemistry via offering huge, immense details on the entire issues in medicinal chemistry of man-made drugs.
Salient Features
- Contains transparent category, man made schemes, mode of motion, metabolism, assay, pharmacological makes use of with the dose and structure–activity courting (SAR) of the next periods of drugs:
- Drugs performing on inflammation
- Drugs performing on breathing system
- Drugs performing on digestive system
- Drugs performing on blood and blood-forming organs
- Drugs performing on endocrine system
- Contains a whole part on chemotherapy and a number of the sessions of chemotherapeutic brokers. additionally comprises fresh subject matters like anti-HIV agents
- Contains short advent concerning the physiological and pathophysiological stipulations of illnesses and their therapy below every one topic
- Provides well-illustrated artificial schemes and substitute artificial routes for majority of gear that assist in fast and stronger figuring out of the subject
- Covers the syllabi of majority of Indian universities
Read or Download Textbook of medicinal chemistry. / Volume II PDF
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Extra resources for Textbook of medicinal chemistry. / Volume II
Sample text
I. b. Amino alkyl ether analogues i. Diphenhydramine (Benadryl, Bendylate) H C O H H C C H H CH3 N CH3 2-(Benzhydryloxy)-N,N-dimethylethanamine 18 Drugs Acting on InŃammation/Allergy Synthesis H C CH2 Br + Br2 / Light HO H H C C H H CH3 N CH3 K 2CO3 Diphenylmethane H C O H H C C H H CH3 N CH3 Diphenhydramine Properties and uses: Diphenhydramine hydrochloride is a white crystalline powder, soluble in water and in alcohol. In addition, to antihistaminic activity, diphenhydramine exhibits antiemetic, antitussive, and sedative properties.
Blood clots are formed when a blood vessel is damaged. A type of PGs called thromboxane (TxA 2) stimulates constriction and clotting of platelets. Conversely, PGI 2 have the opposite effect on the walls of blood vessels. 2. Certain PGs are involved in the induction of labour and other reproductive processes. PGE2 causes uterine contractions and has been used to induce labour. Prostaglandins 47 Nomenclature 7 9 1 3 5 COOH 8 4 16 6 14 10 2 18 20 12 11 13 15 17 19 Prostanoic acid PGs are considered as analogues of poly unsaturated fatty acids.
Dose: Usual dose is 25–50 mg for adults taken orally three to four times per day. P. iii. Thonzylamine (Resistab) H H3CO C H H C C H N H N H N CH3 N CH3 N-(4-Methoxybenzyl)-N-(2-(dimethylamino)ethyl)pyrimidin-2-amine Synthesis H NH2 CH2Cl + H3CO p-Methoxybenzylchloride N H3CO N H N –HCI Pyrimidin-2-amine Cl H3CO N C H N N + –HCI H NH C H H C C H N H CH 3 H H C C H H CH3 N CH3 2-Chloro-N, N-dimethylethanamine N CH3 Thonzylamine Properties and uses: It is recommended for use with streptomycin in exudative human tuberculosis.