By Karen Baxter
This re-creation keeps to supply the busy surgeon with a small and very easily sized speedy reference "Stockley" textual content. "Stockley's Drug Interactions Pocket better half 2009" attracts at the wealth of clinically evaluated, evidence-based info on drug-drug, drug-herb and drug-food interactions that's offered within the complete reference paintings, "Stockley's Drug Interactions".
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Extra info for Stockley's Drug Interactions 2009 Pocket Companion
Sample text
Amiodarone + Lidocaine Isolated reports describe a seizure in a man taking lidocaine about 2 days after he started to take amiodarone, and sinoatrial arrest in another man with sick sinus syndrome who was given both drugs. There is conflicting evidence as to whether or not amiodarone affects the pharmacokinetics of lidocaine. Careful monitoring is required if both drugs are used. Amiodarone + Lithium Hypothyroidism developed very rapidly in 2 patients taking amiodarone when lithium was started.
G. of renal function) would seem appropriate if high doses of furosemide are given. The same precautions would seem to be appropriate with other loop diuretics. Aminoglycosides + NRTIs The aminoglycosides are known to be nephrotoxic and many of their interactions occur as a result of this effect. Due to the number of known interactions with other nephrotoxic drugs (for examples see amphotericin, page 38, and ciclosporin, page 38), many manufacturers of other drugs with nephrotoxic effects, including tenofovir, caution concurrent use.
Monitor blood pressure and/or disease control, and adjust the doses/treatment accordingly. Potassium-sparing diuretics Based on experience with the use of other substances that affect the renin-angiotensin system, the concurrent use of potassium-sparing diuretics and aliskiren may lead to increases in serum potassium. Additive hypotensive effects likely when aliskiren is given with any diuretic, see antihypertensives, page 77. Monitor potassium levels and adjust treatment as necessary. Allopurinol Allopurinol + Antidiabetics Although allopurinol affects the half-life of chlorpropamide and tolbutamide, and a case of diabetic coma has been seen in a patient taking gliclazide and allopurinol, there appears to be little information to suggest that a clinically significant interaction usually occurs with sulphonylureas.