By Timothy RJ Nicholson, Donald RJ Singer
A brand new annual version of this well known pocket drug consultant. it's absolutely up-to-date with the inclusion of latest medicines and with outdated medicinal drugs being got rid of. It offers the main crucial medical pharmacology details that busy clinicians desire through concentrating on the main commone 500 pharmaceuticals.
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Vii) Dose: according to age; all doses can be given up to max frequency qds (min dose spacing ϭ 4 h): 3 months–1 year 60–120 mg, 1–5 years 120–250 mg, 6–12 years 250–500 mg, Ͼ12 years 500–1000 mg (ϭ adult dose). NB: Two strengths available: ‘standard’ Paediatric (120 mg/5 ml) and stronger 6 Plus (250 mg/5 ml). CANDESARTAN/AMIAS Angiotensin II antagonist. Use: HTN1 (for advice on stepped HTN Mx see p. 178) or HF2 (when ACE-i not tolerated). CI: cholestasis, L (if severe)/P/B. Caution/SE/Interactions: see Losartan.
AMOXICILLIN Broad-spectrum penicillin; good GI absorption (can give po and iv). Use: mild pneumonias1 (esp community-acquired), UTI, Listeria meningitis, endocarditis Px and many ENT/dental/other infections. Often used with clavulanic acid as co-amoxiclav. CI/Caution/SE/Interactions: see Ampicillin. Dose: 500–1000 mg tds po/iv1; for other severe infections see SPC/BNF (mild/moderate infections usually 250–500 mg tds po). NB: Ødose in RF. 13 14 COMMON/USEFUL DRUGS AMPICILLIN Broad-spectrum penicillin for iv use: has ØGI absorption cf amoxicillin, which is preferred po.
Very rarely fi seizures. Also, fluconazole fi ≠serum levels. Mild W؉. Dose: 100–200 mg bd po. Ødose in RF*. Consider gastroprotective Rx. COX-2 inhibitors and ≠risk of cardiovascular complications: CSM advises assessment of cardiovascular risk and use in preference to other NSAIDs only if at ≠≠risk of GI ulcer, L/R/H ϭ Liver, Renal and Heart failure (full key see p. vii) perforation or bleeding. Use lowest effective dose and duration. CEPH– see CEF– CETIRIZINE/ZIRTEK Non-sedating antihistamine: selective peripheral H1 antagonist; antimuscarinic.