By Yie Chien
A finished remedy of the technology, expertise, and rules of rate-controlled management of healing brokers, with assurance of the elemental options, basic ideas, biomedical rationales, and power functions. This revised and up-to-date variation (first in 1982) contains
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P. Sarpotdar; Comparative controlled skin permeation of introglycerin from marketed transdermal delivery systems. J. Pharm. , 72:968 (1983). 40 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. Chapter 1 A. Karim; Transdermal absorption: A unique opportunity for constant delivery of nitroglycerin. Drug Develop. & Ind. , 9:671 (1983). Y. W. -Y. Chien and Y. C. S. Patent 4,818,540 (April 4, 1989). -Y. Chien, Y. C. Huang and Y. W. Chien; In: Abstracts of the Japan-United States Congress of Pharmaceutical Sciences (1987), No.
For instance, a gastric fluid-labile drug is protected by encapsulating it inside a polymer membrane that resists the degradative action of gastric pH, such as the combination of ethylcellulose and hydroxylmethylcellulose phthalate (Figure 26). In the stomach, the coating membrane resists the action of gastric fluid (pH < 3) and the drug molecules are thus protected from acid degradation. 5) activates the erosion of the intestinal fluid-soluble hydroxylmethylcellulose phthalate component from the coating membrane.
Rate-preprogrammed drug delivery systems Activation-modulated drug delivery systems Feedback-regulated drug delivery systems All three categories of controlled-release drug delivery systems (Figure 1) consist of the following common structural features: 1. 2. 3. Drug reservoir compartment Rate-controlling element Energy source As discussed in Chapter 1, the rate-preprogrammed drug delivery system can be viewed as the first generation of controlled-release drug delivery systems (DDS), providing the technological basis for the later development of activation-modulated drug delivery systems, as the second generation of controlled-release DDS, and of feedback-regulated drug delivery systems, as the third generation of controlled-release DDS.