By Isaac Ghebre-Selassie
content material: Manufacture of middle pellets by way of balling / Lucy S.C. Wan --
coaching of micropellets through spray congealing / A. Atilla Hincal, H. Suheyla Kas --
Cryopelletization / Axel Knoch --
Coating of multiparticulates utilizing polymeric suggestions: formula and approach concerns / Klaus Lehmann --
Coating of multiparticulates utilizing molten fabrics: formula and approach issues / David M. Jones, Phillip J. Percel --
Suspensions and dispersible dosage different types of multiparticulates / Roland Bodmeier, Ornlaksana Paeratakul --
Multiparticulate encapsulation apparatus and method / Donald okay. Lightfoot --
Compaction of multiparticulate oral dosage types / Metin Celik --
Key components within the improvement of modified-release pellets / Stuart C. Porter, Isaac Ghebre-Sellassie --
Mechanisms of unencumber from covered pellets / Jennifer B. Dressman ... [et al.] --
Biopharmaceutical elements of multiparticulates / Johannes Kramer, Henning Blume --
In vivo habit of multiparticulate as opposed to single-unit dose formulations / George A. Digenis. (cont) tablet shell composition and production / Ronnie Millender --
Packaging of multiparticulate dosage types: fabrics and kit / K.S. Murthy, Franz Reiterer, Jurgen Wendt --
advertising issues for multiparticulate drug supply platforms / Roland Daumesnil.
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In case of aseptic processing, sterile liquid nitrogen is required, which can be produced using Cryobran, a lowtemperature filter equipment of Buse Gase, which also allows conventional filter integrity testing at — 196°C. III. PROCESSING VARIABLES The most critical step in producing spherical particles by globulation is the droplet formation process itself. The formation of drops is influenced on the one hand by formulation-related variables such as viscosity, surface tension, and the solids content.
5 mm are important in pharmaceutical technology. The characteristics of congealed micropellets are also governed by the particle size of the product. This factor is particularly important in controlling the distribution and average particle size of the active substance in the matrix. Scott et al. were the first to conduct an extensive study on the factors influencing the size and size distribution of spray-congealed particles [5]. They showed that variables such as atomizer wheel speed, feed rate, and feed velocity influenced the size of the pellets.
3). The addition of lecithin improves the surface morphology as shown. Apart from the solvent effect, the chain length of the glycerides also plays an important role in the surface morphology of micropellets. Eldem et al. [2] showed the effect of the chain length of glycerides on the surface morphology of formulations containing Dynasan 116 and Tripalmitin. The authors also observed smooth surface morphology with Compritol 888, which is a mixture of mono, di, and tribehenate. Due to the absence of solvent evaporation, the IPfllK Fig.