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6 Solvent Evaporation from Charged Droplets Causes Coulomb Fissions of Droplets The charged droplets produced by the spray needle shrink due to solvent evaporation while the charge remains constant. 2 Production of Gas-Phase Ions by Electrospray and Electrospray Ionization Mass Spectrometry the charges at the surface increases and at a certain droplet radius the repulsion of the charges overcomes the cohesive force of the surface tension. This instability results in fission of the droplet, at which point the droplet typically releases a jet of small, highly charged, progeny droplets.

As will be shown below, a large loss of solvent by evaporation occurs before the final droplets are formed that lead to ions. It is instructive and for certain applications desirable to estimate the increase in solute concentration due to the volume lost by evaporation. 5. It deals with droplets produced by nanoelectrospray. 5 Droplet history of charged water droplets produced by nanospray. First droplet is one of the droplets produced at spray needle. This parent droplet is followed over three evaporation and fission events.

8). A third effect can also be expected. 5. 2 Production of Gas-Phase Ions by Electrospray and Electrospray Ionization Mass Spectrometry higher surface-to-volume ratios relative to the parent droplets, a large enrichment of the surface active ions is expected for the progeny droplets. More recent work by Enke [38a], starting from somewhat different premises, led to further advances in predicting and understanding relative ion intensities. Instead of working with the ion currents I, IA, a conversion to mole charge/liter was used.

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