By David T. Rossi, Michael Sinz
13 chapters summarize the speculation, instrumentation, and alertness of mass spectrometry and atmospheric strain ionization to the review of drug applicants. It describes present ideas in pharmaceutics and pharmacokinetics for elevated amounts of recent pharmacological compounds. Chapters speak about ion chemistry and fragmentation, the LC/MS scan, drug hydrophobicity and delivery, drug metabolism, cassette dosing, microdialysis, and comparable topics. participants contain chemists at universities and researchers for drug businesses. Annotation c. booklet information, Inc., Portland, OR (booknews.com)
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Chromatographia, 21:342, 1986. 11. WH McFadden, DC Bradford, G Eglinton, SK Hajbrahim, N Nicolaides. Application of combined liquid chromatography/mass spectrometry (LC/MS): analysis of petroporphyrins and meibomian gland waxes. J Chromatogr Sci 17:518–522, 1979. 12. MA Baldwin, FW McLafferty. Liquid chromatography mass spectrometry interface—I: the direct introduction of liquid solutions into a chemical ionization mass spectrometer. Org Mass Spectrom 7:1111–1112, 1973. 13. AP Bruins. Developments in interfacing microbore HPLC with mass spectrometry (a review).
To generalize, electrospray ionization is more Copyright © 2002 Marcel Dekker, Inc. Mass Spectrometry Primer 45 applicable to high-molecular-weight compounds, as electrospray ionization requires less heat and has the potential to produce multiply charged ions. Less polar molecules, such as steroids, generally ionize better by APCI. However, for the majority of pharmaceutical drug candidates, compounds with some acidic or basic characteristics and with relatively low molecular weight, either electrospray ionization or APCI is applicable.
Mass Spectrometry Primer 49 mass spectrum generation. If the RF/DC is held constant, only a narrow m/z range will traverse the quadrupole, and in this configuration the quadrupole mass spectrometer acts as a mass filter. The resolution of this stable mass range can be modified, but in general a quadrupole mass filter is configured to provide selectivity to discriminate against ions differing by more than one m/z unit. It is this configuration that is exploited for quantitation because selective detection of a single m/z ion is possible in the presence of a milieu of ions.