By Michael and Irene Ash
The guide of Pharmaceutical ingredients, 3rd variation has been widely up to date from the former variation, which used to be released in 2002. It describes greater than 5300 alternate identify items and 4000 customary chemical compounds and fabrics, on hand from all over the world brands, that functionality as pharmaceutical ingredients. Pharmaceutical ingredients are outlined during this reference as secondary parts found in either prescription and over the counter drug formulations and contributing in a single or extra of the next methods: bettering intake ease of the dosage shape via protecting disagreeable scent, bettering palatibility or visual appeal of the energetic factor. allowing or bettering the supply of the drug or medication that's on hand in a number of dosage kinds (i.e., oral; topical, ophthalmic, and otic; suppositories; injectables; inhalants) and hence enhancing its efficacy, regulate of bioavailability, uniformity, and/or circulate features expanding the steadiness of lively elements performing as a filler or diluent in order that an enough volume of fabric is accessible to correctly fill a dosage shape performing as an antimicrobial or antioxidant to increase the shelf lifetime of the energetic component therefore, the definition of pharmaceutical ingredients for the aim of this paintings encompasses excipients, synergists, or chemical substances that substantively give a contribution to the effectiveness of the lively factor. Entries for either exchange names and chemical substances include wide info accumulated from all over the world brands, vendors, exchange journals, govt records, and different reference resources. The instruction manual of Pharmaceutical ingredients, 3rd variation centralizes and integrates info on those chemical substances and fabrics thereby serving as a vital advisor to product managers, formula scientists, caliber controllers, aspect chemists, pharmacists, physicians, and shoppers. Contents booklet half I-Trade identify Reference exchange identify Reference includes over 5300 alphabetica
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Additional info for Handbook of Pharmaceutical Additives, Third Edition (Ash, Handbook of Pharmaceutical Additives)
Example text
Sol. 5% in min. oil, xylene; dens. 6 lb/gal; visc. 6; pour pt. 9 C; flash pt. 293 C; sapon no. 197; nonionic; 100% act. Agnique GLY 99-U [Cognis/Chems. com] Chem. : Glycerin CP/USP CAS 56-81-5; EINECS/ELINCS 200-289-5 Uses: Visc. modifier, flavor enhancer, moisturizer, solvent, humectant, thickener, and solubilizer in drug vehicles Regulatory: EPA exempt Properties: Water-wh. visc. ; odorless; sol. gr. p. p. 171 C; pour pt. 18 C; flash pt. 5% min. 6 g/kg; mild eye irritant, moderate skin irritant; inhalation of mist may cause respiratory irritation Storage: Store in cool, dry area; avoid excessive heat, open flames; incompat.
Shelf life in original, unopened container protected from light; store @ cool temps. Alcolec® PS 50 P [Am. com] Chem. ) as a flow agent See Calcium phosphate tribasic Chem. Analysis: 50% min. 0% max. moisture CAS 8030-76-0; 1306-06-5; EINECS/ELINCS 310-129-7; 231-840-8. ; disp. in water and paraffin (50 g/l); mild typical odor; dens. <1 g/cm3; pH 5-8 (10 g/l water); nonionic Environmental: Biodegrad. Precaution: Do not expose to direct heat or open fire; avoid strong oxidizers Storage: 2 yr. T.
Com; Harwick Std. Distrib. com] Chem. w. polymeric adipate Uses: Plasticizer for medical applics. ; washable; permanent Regulatory: FDA sanctioned Properties: Lt. colored cl. bright fluid to visc. w. gr. 080; visc. 3380 cps; pour pt. 40 F; acid no. 1; hyd. no. 20; flash pt. 545 F; ref. asp] Chem. : Glucose syrup and fructose See Glucose, liquid Chem. 7% 29 Trade Name Reference CAS 8029-43-4; 57-48-7; EINECS/ELINCS 232436-4; 200-333-3 Uses: Sweetener , humectant, crystallization control agent, viscosity reducer, flavor enhancer flavor and color development aid, texture softener, water activity reducer, and freeze point depressant in pharmaceutical syrups Properties: Cl.