By Albrecht Messerschmidt
The 1st volumes of the "Handbook of Metalloproteins", released in 2001, concerned with a couple of metals, together with iron, nickel, manganese, cobalt, copper and vanadium. Now we're thrilled to provide quantity 3 which extends the wealth of information and specializes in proteins present in the redox-inactive ions of zinc and calcium.* color illustrations all through* 3D constructions of transformed metalloproteins for simpler figuring out of services* foreign professional contributorsThe striking new set will end up to be a vital reference offering complete figuring out and centred assurance of metalloproteins."it is a excitement to exploit ...this very good, authoritative, and invaluable text...I regard this paintings as crucial for library purchase..." (Natural items file, Vol.19, No.4, 2002)"highly advised as a source for bioinorganic chemistry. it's going to have lasting worth for researchers within the box" (The Alchemist - Chemweb, 2002)
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Example text
This reputation for toxicity clearly has not been advantageous for the development of therapeutic applications for organometallic compounds, although a more favorable tendency is in evidence for the derivatives of silicon, phosphorus or germanium [84–86]. It should be noted, however, that although attaching organic groups directly to the metal may increase toxicity, this is not always the case. It was noted earlier that organic compounds of arsenic are less toxic than their inorganic analogs and that this observation led to Ehrlich’s pioneering work on chemotherapy.
3 Toxicology and the Environment Minamata disease was the name given to organomercury poisoning following the first reported large-scale event of this type, to which the inhabitants of the Minamata Bay area in Japan fell victim in 1953. The toxin was CH3-Hg-SCH3 [75], from the shellfish Hormonya mutabilis, but downstream of the effluents of a factory preparing acetaldehyde [76]. Owing to these serious toxicological problems, the biology of methyl mercuric chloride is the most intensely studied of all organometallics [44].
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