By Buhler V.
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Experiments such as this though can be important as they allow the study of any drug on its effects in modulating specific neuronal circuits and receptors. v. injection may not be able to cross the blood-brain barrier and be bioavailable to the brain, if promising pharmacological results are obtained, it would validate a potential target and warrant future work on developing analogs that are bioavailable. 26 Rats were placed in a test chamber called a Skinner Box, a more modern term is operant conditioning chamber, and electrodes were implanted in various parts of the brain.
We will see how drugs of abuse often indirectly affect dopamine levels via interaction with a different neurotransmitter system. An understanding of neuroanatomy and neurocircuitry is important to appreciate the levels of interdependence of neurotransmitter systems and the actions of drugs of abuse. Each drug of abuse is different but commonalities can occur such that a drug useful for the treatment of narcotic addiction can be potentially useful for the treatment of alcoholism. The drugs of abuse bind to their protein targets where they elicit a biological response, that is, they act as agonists.
The chapter will consist of two broad sections, though the goal of the discussion is to integrate them into a continuous theme. The two broad sections are the neurobiology of addiction and the neurochemistry of addiction. This subject is a vast area of information that cannot be fully covered in this book. The interested reader who desires a more detailed understanding can consult the many excellent texts devoted to this subject. Appendix A contains a list of books pertinent toward gaining a deeper understanding of the neurobiology and neurochemistry of addiction.