By Johannes Kirchmair, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

The 1st expert reference in this hugely correct subject, for drug builders, pharmacologists and toxicologists.
The authors supply greater than a scientific assessment of computational instruments and information bases for drug metabolism learn and their underlying ideas. they target to show their specialist wisdom distilled from decades of expertise within the box. as well as the basics, computational methods and their functions, this quantity offers specialist money owed of the newest experimental equipment for investigating drug metabolism in 4 committed chapters. The authors speak about an important caveats and customary blunders to contemplate while operating with experimental data.
Collating the data received during the last decade, this practice-oriented advisor provides equipment not just utilized in drug improvement, but additionally within the improvement and toxicological evaluation of cosmetics, practical meals, agrochemicals, and ingredients for buyer items, making it a useful reference in quite a few disciplines.

Show description

Read or Download Drug Metabolism Prediction PDF

Similar pharmacy books

Free Energy Calculations in Rational Drug Design

Loose strength calculations signify the main exact computational strategy to be had for predicting enzyme inhibitor binding affinities. Advances in machine energy within the Nineties enabled the sensible software of those calculations in motive drug layout. This booklet represents the 1st complete overview of this transforming into sector of study and covers the elemental idea underlying the strategy, various cutting-edge innovations designed to enhance throughput and dozen examples in which loose strength calculations have been used to layout and overview strength drug applicants.

The School of Pharmacy, University of London. Medicines, Science and Society, 1842–2012

The varsity of Pharmacy, collage of London: drugs, technological know-how and Society, 1842-2012 represents the wealthy background of the collage of London university of Pharmacy via a number of colour images, vital advances within the pharmacy occupation, cultural milestones, biographies and extra. Written in an enticing and authoritative sort, this ebook depicts the chronological historical past of the varsity from its institution in 1842 to the current day with a nod towards its aspirations for the longer term.

Venom Genomics and Proteomics

This quantity offers the reader with contemporary advances within the fields of molecular toxinology, the biotechnological functions of venom pollution, and antivenom construction. The content material of the twenty chapters of Venom Genomics and Proteomics illustrates not just the large growth made because the implementation of omics applied sciences within the box of toxinology, yet one additionally realizes the line nonetheless forward to arrive a holistic view of venomous platforms.

Pharmaceutical Process Scale-Up

Targeting clinical and useful elements of technique scale-up, this source information the idea and perform of shifting pharmaceutical approaches from laboratory scale to the pilot plant and construction scale. It covers parenteral and nonparenterel beverages and semi-solids, items derived from biotechnology, dry mixing and powder dealing with, granulation and drying, fluid mattress purposes, compaction and tableting, and picture coating and regulatory necessities for scale-up and postapproval alterations.

Additional info for Drug Metabolism Prediction

Example text

Weekley, J. C. (2006) Bioactivation of carboxylic acid compounds by UDPglucuronosyltransferases to DNAdamaging intermediates: role of glycoxidation and oxidative stress in genotoxicity. Chemical Research in Toxicology, 19, 683–691. , and Shanmugan, G. (2011) Chemistry and structural biology of DNA damage and biological consequences. Chemistry & Biodiversity, 8, 1571–1615. , and De Ponti, F. (2005) QT prolongation through hERG K+ channel blockade: current knowledge and strategies for the early prediction during drug development.

5 (eds B. Testa and H. B. J. Triggle), Elsevier, Oxford, pp. 231–257. P. (2005) Influence of macromolecular crowding upon the stability and state of association of proteins: predictions and observations. Journal of Pharmaceutical Sciences, 94, 1668–1675. J. G. (2004) Cellular models for ADMET predictions and evaluation of drug–drug interactions. Current Opinion in Drug Discovery and Development, 7, 86–99. Nurse, P. (2003) Understanding cells. Nature, 424, 883. Davies, P. (2013) What’s really going on in those cancer cells?

2007) Principles of drug metabolism 2: hydrolysis and conjugation reactions, in ADME-Tox Approaches, vol. 5 (eds B. Testa and H. B. J. Triggle), Elsevier, Oxford, pp. 133–166. A. E. (2007) Principles of drug metabolism 3: enzymes 15 16 17 18 19 20 21 22 23 24 25 and tissues, in ADME-Tox Approaches, vol. 5 (eds B. Testa and H. B. J. Triggle), Elsevier, Oxford, pp. 167–191. Testa, B. D. (2006) The biochemistry of drug metabolism – an introduction. Part 1: principles and overview. Chemistry & Biodiversity, 3, 1053–1101.

Download PDF sample

Rated 4.93 of 5 – based on 31 votes