By Jie Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth
Written via participants of Pfizer international study and improvement for chemists coming into the pharmaceutical undefined, this paintings profiles the synthesis of fourteen consultant pharmaceutical items to be able to display the multidisciplinary nature of the exercise. for every drug, they supply a historic creation and the organic, pharmacological, pharmakinetic, and drug metabolism history ahead of detailing the drug's synthesis.
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Hordis, C. K. J. Am. Chem. 1971,93,2974-2981. 13. ; Wilson, P. ; Fallis, A. G. Tetrahedron Lett. 2000,41, 17-20. 14. ; Dolling, U. ; Frey, L. ; Tillyer, R. ; Tschaen, D. M. WO 98/004 16. Contemporary Drug Synthesis 20 15. Marx, J. Science 2001,291, 581-582. 16. ; Martel, A. ; Castaiier, J. Drugs Fut. 1997,22, 711-714. 17. Review on rofecoxib, Sorbera, L. ; Leeson, P. A,; Castaiier, J. Drugs Fut. 1998, 23, 1287-1296. Contemporary Drug Synthesis. Jie-Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D.
E. WO 9118895 (1991). 8. ; Jereb, D. WO 0002876 (2000). 9. ; Lindberg, P. J. Chromatography 1990, 532,305-3 19. 10. WO 9208716 (1992). 11. Lindberg, P. ; Von Unge, S. WO 9427988 (1994). 12. Lindberg, P. ; Von Unge, S. US 5714504 (1998). 13. ; Moller, E. WO 9854171 (1998). 14. ; Taylor, S. WO 9617076 (1996). Contemporary Drug Synthesis. Jie-Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth Copyright 0 2004 John Wiley & Sons, Inc. ISBN: 0-47 1 -2 1480-9 Chapter 4. Protein-tyrosineKinase Inhibitors: Gleevec’ and Iressa@ 29 Chapter 4.
Science 2001,291, 581-582. 16. ; Martel, A. ; Castaiier, J. Drugs Fut. 1997,22, 711-714. 17. Review on rofecoxib, Sorbera, L. ; Leeson, P. A,; Castaiier, J. Drugs Fut. 1998, 23, 1287-1296. Contemporary Drug Synthesis. Jie-Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth Copyright 0 2004 John Wiley & Sons, Inc. ISBN: 0-47 1 -2 1480-9 Chapter 3. H'K-ATPase Inhibitors: Esomeprazole (Nexium") 21 Chapter 3. H+/K+-ATPaseInhibitors: Esomeprazole (Nexium@) USAN: Omeprazole Trade Name. W. 345 21 USAN.