By Hildebert Wagner, Rudolf Bauer, Dieter Melchart, Anton Staudinger

Volume IV of this handbook offers an summary of the analytical research of various extra chinese language natural medicinal drugs, that are most typically utilized in conventional chinese language drugs (TCM). The certain chromatographic research of the most compounds is illustrated in colored TLC-photographs and HPLC-peak profiles. additional bioactive homes, pharmacological and organic actions of all unmarried natural medications, in addition to their healing functions are mentioned. including Volumes I - III this present quantity represents the main finished assessment to analytical reviews of these natural medicines out there and hence serves as vital handbook for researchers and laboratories devoted to TCM. the standard evidence of the research meets the normal of the eu Drug Regulatory Authority.

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Extra info for Chromatographic Fingerprint Analysis of Herbal Medicines Volume IV: Thin-Layer and High Performance Liquid Chromatography of Chinese Drugs

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1007/978-3-319-32328-2_5, © Springer International Publishing Switzerland 2016 37 Fructus Kochiae – Difuzi Main constituents: -Triterpene saponins [5–10, 12, 14–19] oleanolic acid, oleanolic acid 3-O-glucuronide, momordin Ic (= kochioside Ic), momordin IIc (momordin Ic 28-β-D-glucopyranosyl ester), momordin Ic 6’-methyl ester, 2’-O-β-D-glucopyranosyl-momordin Ic, 2’-O-β-Dglucopyranosyl-momordin IIc, kochianoside I-IV, scoparianosides A-C -Flavonol glycosides [20] Quercetin-7-O-β-D-glucopyranoside, quercetin-7-O-β-D-sophoroside, quercetin-3-O-β-D-apiofuranosyl-(1 → 2)-β-D-galactopyranoside, quercetin-3-O-β-D-apiofuranosyl-(1 → 2)-β-D-galactopyranosyl7-O-β-D-glucopyranoside, quercetin-3-O-α-L-rhamnopyranosyl-(1 → 6)β-D-galactopyranosyl-7-O-β -D-sophoroside, quercetin-3-O-βD-galactopyranosyl-7-O-β-D-glucopyranoside Minor constituents: Alkaloids [12, 15, 21] Phytoecdysteroids [15] Fatty acids (5-hexadecenoic acid) [22] Reported pharmacology: -anti-fungal [12] -anti-inflammatory [5–7, 9, 10, 17, 23] -antiallergic [5, 6, 8, 9, 17] -antipruritic [5, 8, 9, 17] -inhibitory activity against dermatomycoses [13] -hepatoprotective [5] -analgetic effect [5] -antinociceptice [5] -peripheral antinociceptive [6, 7, 9, 10, 17, 23] -antidiabetic [6] -pro-apoptotic [10] -gastroprotective effects [10] -inhibits ethanol and indomethacin-induced gastric mucosal lesions [17] -inhibits glucose uptake in the small intestine [17] -induces HepG2cell apoptosis in a ROS-mediated PI3K and MAPK pathway-dependent manner [14, 16] -contraction of the ileum caused by histamine or barium chloride [13] 38 Fructus Kochiae – Difuzi Fig.

Quality assessment of raw and processed Arctium lappa L. through multicomponent quantification, chromatographic fingerprint, and related chemometric analysis.  Sep. Sci. 38(9), 1491–1498 (2015) 21. : Arctigenic acid, the key substance responsible for the hypoglycemic activity of Fructus Arctii. Phytomedicine 22(1), 128–137 (2015) 22. : Determination of the major constituents in fruit of Arctium lappa L. by matrix solid-phase dispersion extraction coupled with HPLC separation and fluorescence detection.

5 ml anisaldehyde is mixed with 10 ml glacial acetic acid, followed by 85 ml methanol and 5 ml concentrated sulphuric acid, in that order. The plate is sprayed with 10 ml, heated at 110 °C for 10 min, then evaluated in VIS and under UV 366 nm Note: The reagent has only limited stability and is no longer useable when the colour has turned to red-violet. 4. 5 Start 1 2 3 4 5 6 T1 T2 T3 T4 Fig. 2a Thin layer chromatogram of the methanol extracts of Fructus Corni, sprayed with Anisaldehyde – Sulphuric acid reagent (VIS) Description of Fig.

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