By Mark Chasin
Experiences the homes, synthesis, and formulations of a few good studied polymers more and more getting used in site-specific or systematic management of pharmaceutical brokers. for every of the polymers, discusses the historical past; chemistry and synthesis; the formula of microcapsules, solv
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Extra info for Biodegradable Polymers as Drug Delivery Systems (Drugs and the Pharmaceutical Sciences)
Significantly higher molecular weights were achieved using shorter reaction times by utilizing cadmium acetate, earth metal oxides, and ZnEt2-H20. The molecular weights ranged from 140,935 to 245,010 with catalysts, in comparison Polyanhydrides as Drug Delivery Systems 45 to the material described above, which had a molecular weight of 116,800 when produced without- catalysts. -toluenesulfonic acid (p-TSA) or basic 4-dimethylaminopyridine (4-DMAP) catalysts were tested, the acid catalyst p-TSA did not show any effect while the basic catalyst (4-DMAP) caused a decrease in molecular weight.
More than 16 days protection was afforded versus on ly 3 days for controls (137). A unique method of formulating delivery systems based on starchl PLA systems was studied (138). In that approach, the goal was to provide a better matrix for delivery of high molecular weight hydrophilic molecules. A hydrophilic material, starch,was combined through graft polymerization to PLA. The carbolactic polymers were then used to entrap bovine serum albumin in microspheres. Considerable effort has been devoted to the development of controlled release formulations for growth hormone, especially porcine and bovine growth hormone.
Tice, T. , Meyers, W. , Schalley, A. , and Redding, T. , Inhibition of rat prostate tumors by controlled release of [D-T rp6] - LHRH from injectable microcapsules, Proc. Int. Symp. Control. ReI. Bioact. , 88, 1984. , Controlled-release of leuprolide acetate from Laet i de / Glycol ide Pol ymers 128. 129. 130. 131. 132. 133. 134. 135. 136. 137. 138. 139. 41 polylactic acid or copoly(lacticl glycolic) acid microcapsules: Influence of molecular weight and copolymer ratio of polymer, Chern. Pharm. , 36, 1502, 1988.