By Robert A. Goodnow Jr.
This e-book comprehensively describes the advance and perform of DNA-encoded library synthesis know-how. jointly, the chapters aspect an method of drug discovery that provides an enticing addition to the portfolio of present hit iteration applied sciences akin to high-throughput screening, structure-based drug discovery and fragment-based screening. The book:
- Provides a useful consultant for figuring out and utilizing DNA-encoded combinatorial chemistry
- Helps chemists generate and display novel chemical libraries of huge dimension and caliber
- Bridges interdisciplinary parts of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
- Shows medicinal and pharmaceutical chemists how one can successfully develop on hand “chemical area” for drug discovery
- Provides specialist and up to date precis of suggested literature for DNA-encoded and DNA-directed chemistry expertise and methods
Read or Download A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery PDF
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Extra resources for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
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2009 Innovator Significance M. L. Snapper, Early example of solidA. H. Hoveyda, phase synthesis to et al. prepare discovery of new catalysts for enantioselective synthesis D. Kassel High-throughput means of purifying compounds libraries S. Schreiber et al. A strategy for expanding structural diversity of small-molecule libraries Transition from Sangerbased to secondgeneration sequencing technology M. Clark et al. Exemplification of DNA-encoded combinatorial library synthesis and assay with very large library Ref.
In 1965, Letsinger and colleagues reported the solid-phase synthesis of a dimer of deoxycytidine (2) . Six years later, Fréchet and Schuerch reported several reactions performed on polystyrene including the formation of a 1,6-linked glucose–glucose disaccharide (3) . In each of these early solid-phase synthesis reports, the authors focused on single-target synthesis and characterization; as such, they are not the first reports of combinatorial chemistry, but it should be clear that these methods established the thinking and some early methodology for the transformation of a chemistry technology into high-throughput and eventually combinatorial endeavors.