By Robert A. Goodnow Jr.

This e-book comprehensively describes the advance and perform of DNA-encoded library synthesis know-how. jointly, the chapters aspect an method of drug discovery that provides an enticing addition to the portfolio of present hit iteration applied sciences akin to high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

  • Provides a useful consultant for figuring out and utilizing DNA-encoded combinatorial chemistry
  • Helps chemists generate and display novel chemical libraries of huge dimension and caliber
  • Bridges interdisciplinary parts of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
  • Shows medicinal and pharmaceutical chemists how one can successfully develop on hand “chemical area” for drug discovery
  • Provides specialist and up to date precis of suggested literature for DNA-encoded and DNA-directed chemistry expertise and methods

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Extra resources for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery

Sample text

Nat. , 27, 1013–1023. 24. Metzker, M. L. (2010). Sequencing technologies—the next generation. Nat. Rev. , 11, 31–46. 18 Just Enough Knowledge… 25. , Syed, B. A. (2013). Commercial prospects for genomic sequencing technologies. Nat. Rev. , 12, 341–342. 26. , Mermod, J. , Kawashima, E. (2000). Solid phase DNA amplification: characterization of primer attachment and amplification mechanism. , 28, e87. 27. , Turcatti, G. (2006). BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies.

2009 Innovator Significance M. L. Snapper, Early example of solidA. H. Hoveyda, phase synthesis to et al. prepare discovery of new catalysts for enantioselective synthesis D. Kassel High-throughput means of purifying compounds libraries S. Schreiber et al. A strategy for expanding structural diversity of small-molecule libraries Transition from Sangerbased to secondgeneration sequencing technology M. Clark et al. Exemplification of DNA-encoded combinatorial library synthesis and assay with very large library Ref.

In 1965, Letsinger and colleagues reported the solid-phase synthesis of a dimer of deoxycytidine (2) [7]. Six years later, Fréchet and Schuerch reported several reactions ­performed on polystyrene including the formation of a 1,6-linked glucose–glucose disaccharide (3) [8]. In each of these early solid-phase synthesis reports, the authors focused on single-target synthesis and characterization; as such, they are not the first reports of combinatorial chemistry, but it should be clear that these methods established the thinking and some early methodology for the transformation of a chemistry technology into high-throughput and eventually combinatorial endeavors.

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